
- Pain-free blood glucose testing is highly desirable for diabetes management which requires frequent blood glucose monitoring. For many decades a search for a non-invasive blood glucose concentration detection method has been a major, yet elusive goal. Optical methods have been confined in the near-infrared where glucose has absorption peaks but is hard to identify due to multiple overlapping absorptions by other blood constituents. The development of clinically viable non-invasive glucose biosensors has been hampered by lack of specificity and sensitivity. In this paper we introduce theoretically and experimentally a new non-invasive method, Wavelength-Modulated Differential Photothermal Radiometry (WM-DPTR), for non-invasive, non-contact blood glucose monitoring. WM-DPTR features glucose specificity and sensitivity by combining laser excitation by two out-of-phase modulated beams at wavelengths near the peak and the baseline of a prominent and isolated mid-IR glucose absorption band. A theoretical photothermal model of WM-DPTR signal generation and detection has been developed. Simulation results on water-glucose phantoms within the human blood-range glucose concentration (0-300 mg/dl) demonstrated high sensitivity and resolution to meet wide clinical detection requirements. The model has also been validated by experimental data of the glucose-water system obtained using WM-DPTR.














